Drug toxicity

Drug-induced liver injury is a major cause of paediatric liver disease including cholestasis, accounting for almost 20% of cases of acute liver failure in children, and is a major reason for liver transplantation.45

Drugs used in newborns including ampicillin and gentamicin for infections, azithromycin for bronchopulmonary dysplasia and indomethacin for patent ductus arteriosus have all been associated with hepatotoxicity.46

45. Amin MD, Harpavat S, Leung DH. Drug-induced liver injury in children. Curr Opin Pediatr 2015;27:625-33.

46. Van Eyken P, Nemolato S, Faa G, Ambu R. Hepatic injury to the newborn liver due to drugs. Curr Pharm Des 2012;18:3050-60.