What causes (rare) cholestasis in paediatric patients?

Once neonatal cholestasis is confirmed, a systematic approach is the key to reliably achieve the diagnosis in order to promptly initiate the specific, and in many cases, life-saving therapy.1

Diagnostic algorithms for cholestasis

MISTAKES TO AVOID AT ALL COSTS 2

Age definitions3

Neonate: 0-30 days

Infant: 1 month-2 years

Young child: 2-6 years

Child: 6-12 years

Adolescent: 12-18 years

MISTAKES TO AVOID AT ALL COSTS 2

Age definitions3

Newborn/neonate: 0-30 days

Infant: 1 month-2 years

Young child: 2-6 years

Child: 6-12 years

Adolescent: 12-18 years

1. Götze T, Blessing H, Grillhösl C, et al. Neonatal cholestasis – differential diagnoses, current diagnostic procedures, and treatment. Front Pediatr. 2015;3:43.

2. Protocole national de diagnostic et de soins : Déficits de synthèse des acides biliaires primaires. In: Génétiques CdRCdlAdVBedC, ed., 2019.

3. 2007; Position paper: Paediatric age categories to be used in differentiating between listing on a model essential medicines list for children. Accessed at World Health Organization  website on April 2020.

CTRS-INSTIT-PLATEDUC-ONG02/20/07/20